Current Issue : July - September Volume : 2019 Issue Number : 3 Articles : 8 Articles
Background: To demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the\norbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and\nin eyes of patients with Graves ophthalmopathy.\nMethods: Forty four eyes of 44 ophthalmologically normal subjects and 28 eyes of 28 patients with Graves\nophthalmopathy were included in the study. After Corvis test, the examiners recorded WEM by air puff. In the patients\nwith Graves ophthalmopathy, the partial correlation coefficient adjusted for age and gender was calculated to analyze the\ncorrelation between exopthalmometry and WEM. Same analysis was repeated for the correlation between and the cross\nsectional area (%) of the extraocular muscles in the orbit CT and WEM.\nResult:..............
Background: Painful ophthalmoplegia can be caused by various etiologies, and broad differential diagnosis is needed.\nCarotid-cavernous fistula (CCF) is a rare cause of painful ophthalmoplegia, and early diagnosis is quite difficult.\nCase presentation: Here, we present a case of paroxysmal painful ophthalmoplegia caused by CCF. The episodic\nsymptoms were nonstereotypical and lasted minutes to hours. Magnetic resonance imaging (MRI) and computed\ntomography angiography (CTA) results were normal, which confounded efforts to determine a diagnosis. Subsequently,\ndigital subtraction angiography (DSA) revealed a posterior-draining CCF. The CCF was treated at an early stage without\nresidual symptoms.\nConclusions: We propose that symptoms could be relapsing or remitting during an early stage of CCF and that\nposterior-draining CCF is prone to misdiagnosis due to atypical manifestations. Normal CTA results cannot exclude\ncarotid-cavernous fistula, and DSA should be performed once CCF is suspected....
Background: To identify thickness variations in the retinal nerve fiber layer around the optic disc and macula in\npatients with cerebral vein thrombosis (CVT) without papilledema.\nMethods: This study included 28 patients with CVT diagnosis and appropriate treatment. Detailed ophthalmologic\nexamination found bilateral vision 10/10, vision field test normal and fundus examination found no papilledema\nimages. The patients had macular and optic retinal nerve fiber layer thickness (RNFL) measured with spectral\ndomain-optical coherence tomography (SD-OCT) (Optovue, Fremont, CA). Patients had retinal nerve fiber thickness\ncompared with a control group.\nResults: When the effect on the macula and RNFL near the optic nerve disk is investigated, there was significant\nthinning identified in the macula inferior inner, temporal inner, superior inner and temporal outer quadrants (p = 0.\n009, 0.001, 0.026, 0.014, respectively) and in the inferior temporal quadrant of the optic nerve disk (p = 0.020) in CVT\npatients compared to normal individuals.\nConclusions: Even after appropriate treatment of CVT patients, axonal loss was identified with OCT. As a result, it\nmay be important to use OCT measurements to monitor CVT treatment....
Introduction. Even though ocular refractive state is highly heritable and under strong genetic control, the identification of\nsusceptibility genes remains a challenge. Several HGF (hepatocyte growth factor) gene variants have been associated with\nocular refractive errors and corneal pathology. Purpose. Here, we assess the association of an HGF gene variant, previously\nreported as associated with hyperopia, and ocular biometric parameters in a multicenter Spanish cohort. Methods. An\nobservational prospective multicenter cross-sectional study was designed, including a total of 403 unrelated subjects\ncomprising 188 hyperopic children (5 to 17 years) and 2 control groups: 52 emmetropic adolescents (13 to 17 years) and 163\nemmetropic young adults (18 to 28 years). Each individual underwent a comprehensive eye examination including cycloplegic\nrefraction, and topographic and ocular biometric analysis. Genomic DNA was extracted from oral swabs. HGF single\nnucleotide polymorphism (SNP) rs12536657 was genotyped. Genotypic, allelic, and logistic regression analyses were performed\ncomparing the different groups. A quantitative trait association test analyzing several biometric parameters was also\nperformed using generalized estimating equations (GEEs) adjusting for age and gender. Results. No association between\nrs12536657 and hyperopia was found through gender-adjusted logistic regression comparing the hyperopic children with\neither of the two control groups. Significant associations between mean topographic corneal curvature and rs12536657 for G/\nA (slope =+0.32; CI 95%: 0.04-0.60;p =0.023) and A/A (slope = +0.76; CI 95%: 0.12-1.40; p = 0.020) genotypes were\nobserved with the age- and gender-adjusted univariate GEE model. Both flat and steep corneal topographic meridians were\nalso significantly associated with rs12536657 for the G/A and A/A genotypes. No association was found between rs12536657\nand any other topographic or biometric measurements. Conclusions. Our results support a possible role for HGF gene variant\nrs12536657 in corneal curvature in our population. To our knowledge, this is the first multicenter quantitative trait association\nstudy of HGF genotypes and ocular biometric parameters comprising a pediatric cohort....
Background: To explore minimal surgery in selected patients with intravitreal foreign body (IVFD) and traumatic cataract.\nMethods: Twelve eyes of 12 patients with small ferrous IVFD and traumatic cataract without endophthalmitis,\nretinal injury and secondary glaucoma, between September 2015 and March 2017 were retrospectively analyzed.\nPrimary removal of IVFD was performed by external magnetic extraction through the pars plana incision.\nSecondary removal of traumatic cataract by phacoemulsification and intraocular lens (IOL) implantation with or\nwithout anterior vitrectomy were performed. Patients were followed up at 1 day, 1 week, 1 month, 3 months,\n6 months and 12 months after surgery.\nResults: All patients were male with a mean age of 32 years old. All IVFDs were successfully removed without\nretinal injury. Two to 6 months later, the traumatic cataract was successfully removed by phacoemulsification\ncombined with IOL implantation in the capsule bag in 10 patients. Anterior vitrectomy was implied in 2 patients\nwith large posterior capsule rupture, and the IOLs were placed in the ciliary sulcus. Best-corrected visual acuity\nranged from hand movement to 20/100 before surgery and improved ranging from 20/32 to 20/20 at the final\nfollow-up. The IOLs were well centered. Complications such as secondary glaucoma, endophthalmitis and retinal\ndetachment were not found.\nConclusions: Primary removal of small ferrous IVFD by external magnetic extraction followed by secondary\ncataract removal and IOL implantation is an appropriate choice. Minimal surgery may obtain good visual\noutcome without complications in selected patients....
The purpose of this study was to investigate the effects of Buddleja officinalis Maxim eye drops on morphology and apoptosis\nin lacrimal glands of the experimental dry eye rabbit model. A total of thirty-six male rabbits were divided into six study\ngroups, consisting of the control group and the dry eye rabbit model group (without any treatment), the dry eye rabbit model\ngroup treated with testosterone, and the dry eye rabbit model group treated with different concentrations of Buddleja\nofficinalis Maxim eye drops (1.0 mg/ml, 1.5 mg/ml and 3.0 mg/ml). The lacrimal glands were evaluated by hematoxylin-eosin\nstaining and immunohistochemistry. Buddleja officinalis Maxim eye drops can improve the morphological structure of the\nlacrimal gland in the dry eye model of castrated rabbits. The average optical density values of PI3K, Akt, and caspase-9 protein\nin the lacrimal gland tissue of the 3 mg/ml Buddleja officinalis Maxim eye drops group were significantly different from those\nin the model group (P< 0.01) and similar to the testosterone control group and the control group (P> 0.05). Buddleja\nofficinalis Maxim eye drops can improve the morphological structure of the lacrimal gland in the dry eye model of\ncastrated rabbits....
Background: To evaluate the effects of anterior capsular opening size on deviation from predicted refraction and\nthe effective position of the intraocular lens (ELP) in cataract surgery.\nMethods: Nonrandomized clinical trial. Eighty patients (80 eyes) with simple age-related cataracts were treated\nfrom May 2018 to September 2018 at the Fourth Affiliated Hospital of China Medical University. All patients\nundergoing phacoemulsification received intraocular lens based on the voluntary principle. Forty eyes were\nimplanted with the C-loop haptic intraocular lens (AMO Tecnis ZCB00) while the other 40 eyes were implanted\nwith the plate haptic intraocular lens (CT ASPHINA 509 M). Follow-up visits were conducted postoperatively at 1\nweek, 1 month, and 3 months during which patients underwent refraction and data collection after pupil dilation,\nwhich included anterior segment photography and Scheimpflug imaging by Pentacam. The area, horizontal and\nvertical diameter of the capsulorrhexis, circularity, decentration, and package were analysed using the image\nanalysis software Image-Pro-Plus 6.0,then evaluated the relationship between the different shapes of capsulorrhexis\nwith deviation from predicted refraction and ELP in cataract surgery.\nResults: Deviation from predicted refraction and all of the parameters of capsulorrhexis were not correlative in the\n509M IOL group, however, in the Tecnis IOL group, while the deviation from predicted refraction and all of the\ncapsulorrhexis parameters were not correlative at 1 week, the deviation from predicted refraction did correlate with\ncapsulorrhexis area, horizontal diameter at 1 month (P = 0.029, P = 0.048), and with capsulorrhexis area, vertical diameter\nat 3months (P = 0.03, P = 0.017). The ELP correlated with package in both groups postoperatively (r > 0, P < 0.05), but\nthere is no other capsulorrhexis parameters correlated with ELP in the 509M IOL group (all P > 0.05). For the Tecnis IOL\ngroup, the ELP and capsulorrhexis area were correlated at 1 week and 1 month, while the ELP and horizontal diameter,\nthe ELP and vertical diameter were correlated at 1 week, but did not correlate with the other capsulorrhexis parameters\nin the Tecnis IOL group (all P > 0.05).\nConclusions: The shape of the capsulorrhexis has an effect on postoperative refractive outcomes and the effective\nposition of the intraocular lens in cataract surgery, and plate haptic intraocular lenses have better refractive stability\nthan C-loop haptic intraocular lenses....
Background: Cataract patients were always excluded from studies on ageing of colour vision; thus, effect of agerelated\ncataracts on deterioration of colour perception has not been analysed. In present study, impacts of agerelated\ncataracts on colour discrimination, postoperative recovery and related spectra were investigated.\nMethods: In this cohort study, thirty age-related cataract patients scheduled for binocular surgery and 30 elderly\nvolunteers were enrolled. Colour discrimination under photopic (1000 lx) and mesopic (40 lx) conditions was evaluated\nwith Farnsworth-Munsell 100-hue test. The total error score (TES) and partial error score (PES) were calculated....
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